Download or read book The Post-polio Syndrome written by Marinos C. Dalakas and published by . This book was released on 1995 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-polio syndrome (PPS) embodies the new neuromuscular symptoms that patients with prior paralytic poliomyelitis develop after a stable course from 20 to 40 years. These include new muscle weakness, fatigue, muscular atrophy, muscle pain and various secondary muscular complaints. Fundamental questions regarding the neurobiology of the motor neurones previously affected by the poliovirus, the ongoing changes of the reinnervating process, and the potential role of the poliovirus in generating a chronic immune stimulation or viral persistence are discussed in this volume. Data from the neurological, immunological, virological, electrophysiological and rehabilitational fields is presented, shedding light on the pathogenesis of post-polio syndrome, as well as that of other motor neurone diseases such as amyotrophic lateral sclerosis (ALS).