Download or read book Synthesis and Applications of Isotopically Labelled Compounds: Proceedings of the International Symposium Held in Innsbruck, Austria on 17-21 July 1988 written by Thomas A. Baillie and published by . This book was released on 1988 with total page 861 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stable isotopes (2H, 13C) are useful for studies on the metabolism of endogenous or exogenous compounds. GC/MS makes it possible to measure partial loss of 2H by exchange from polydeute-rated molecules and to detect compartmentation of precursors. Oxidoreduction can be studied by measurements of the loss of isotope from the carbon carrying the hydroxyl group. Label in the coenzyme can be corrected for by the use of mixtures of differently labelled compounds. Isotope effects can be used to study mechanisms in vitro and pathways in vivo. Labelling in vivo with 2H-substrates makes it possible to distinguish coenzyme pools. Topics discussed in this symposia include: Synthesis and Applications of Organic Compounds Labelled With Isotopic Hydrogen; Applications of Stable Isotopes and NMR Spectroscopy for In Vivo Studies; Radiation-Induced Reactions; Applications of Isotopically-Labelled Compounds in Clinical Research; Isotopes in Organic and Bio-Organic Reaction Mechanisms; New Techniques in Isotopic Analysis; Synthesis and Application of Organic Compounds Labelled With Iodine Isotopes; Synthesis of Isotopically-Labelled Compounds Via Organometallic Chemistry; Synthesis and Applications of Organic Compounds Labelled With Isotopic Carbon, Sulphur and Other Isotopes; The Use of Isotopically Labelled Compounds in Studies of Drug Metabolism, Disposition and Toxicity; Synthesis and Applications of Labelled Compounds in Positron Emission Trans-Axial Tomography; Applications of Radioactively-Labelled Compounds to In Vitro and In Vivo Research.(AW).