Download or read book Statistical Physics of Folding and Aggregation of Amyloid [beta]-protein of Alzheimer's Disease written by Sijung Yun and published by . This book was released on 2007 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: We use a discrete molecular dynamics simulation method to study aggregation of Abeta40 and Abeta42. Our simulations with hydrophobic and hydrophilic interactions show the distributions of Abeta40 and Abeta42 aggregates are significantly different, in agreement with the experimental results. We show that the difference between Abeta40 and Abeta42 occurs already at the folding stage. Abeta42 folded structure is characterized by a turn in the C-terminus that is not present in Abeta40. We show that the amino acids in the same C-terminal region are also responsible for the strongest intermolecular contacts in Abeta42 aggregates, but not in Abeta40 aggregates.