Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
Author :
Publisher : CRC Press
Total Pages : 252
Release :
ISBN-10 : 9781466556270
ISBN-13 : 1466556277
Rating : 4/5 (277 Downloads)

Book Synopsis Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research by : Chul Ahn

Download or read book Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research written by Chul Ahn and published by CRC Press. This book was released on 2014-12-09 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies. For clustered studies, the authors provide sample size formulas that account for variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas that account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the authors describe how randomization impacts trial administration, analysis, and sample size requirement.


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