Next Generation Kinase Inhibitors

Next Generation Kinase Inhibitors
Author :
Publisher : Springer Nature
Total Pages : 224
Release :
ISBN-10 : 9783030482831
ISBN-13 : 3030482839
Rating : 4/5 (839 Downloads)

Book Synopsis Next Generation Kinase Inhibitors by : Paul Shapiro

Download or read book Next Generation Kinase Inhibitors written by Paul Shapiro and published by Springer Nature. This book was released on 2020-07-14 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.


Next Generation Kinase Inhibitors Related Books

Next Generation Kinase Inhibitors
Language: en
Pages: 224
Authors: Paul Shapiro
Categories: Medical
Type: BOOK - Published: 2020-07-14 - Publisher: Springer Nature

GET EBOOK

Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phospha
Kinase Drug Discovery
Language: en
Pages: 333
Authors: Richard A. Ward
Categories: Medical
Type: BOOK - Published: 2012 - Publisher: Royal Society of Chemistry

GET EBOOK

Kinase drug discovery remains an area of significant interest across academia and in the pharmaceutical industry. There are now around 13 FDA approved small mol
Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?
Language: en
Pages: 245
Authors: Kulmira Nurgali
Categories:
Type: BOOK - Published: 2018-06-12 - Publisher: Frontiers Media SA

GET EBOOK

Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effec
Structural Biology in Drug Discovery
Language: en
Pages: 1437
Authors: Jean-Paul Renaud
Categories: Medical
Type: BOOK - Published: 2020-01-09 - Publisher: John Wiley & Sons

GET EBOOK

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biolog
Protein Kinase Inhibitors
Language: en
Pages: 832
Authors: Md. Imtaiyaz Hassan
Categories: Science
Type: BOOK - Published: 2022-05-19 - Publisher: Academic Press

GET EBOOK

Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in di