Multiple Testing Procedures with Applications to Genomics
Author | : Sandrine Dudoit |
Publisher | : Springer Science & Business Media |
Total Pages | : 611 |
Release | : 2007-12-18 |
ISBN-10 | : 9780387493176 |
ISBN-13 | : 0387493174 |
Rating | : 4/5 (174 Downloads) |
Download or read book Multiple Testing Procedures with Applications to Genomics written by Sandrine Dudoit and published by Springer Science & Business Media. This book was released on 2007-12-18 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.