Download or read book Methods Development in Quantum Mechanics and Molecular Mechanics for Drug Discovery written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of a novel algorithm for treating interloop interactions in proteins will be presented in the context of the Protein Local Optimization Program (PLOP). Finally, the details of a next-generation scoring function, called WSCORE, for molecular docking is presented along with application to MCL-1.