Colonic Motility

Colonic Motility
Author :
Publisher : Biota Publishing
Total Pages : 159
Release :
ISBN-10 : 9781615041510
ISBN-13 : 1615041516
Rating : 4/5 (516 Downloads)

Book Synopsis Colonic Motility by : Sushil K. Sarna

Download or read book Colonic Motility written by Sushil K. Sarna and published by Biota Publishing. This book was released on 2010-11-01 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.


Colonic Motility Related Books

Colonic Motility
Language: en
Pages: 159
Authors: Sushil K. Sarna
Categories: Medical
Type: BOOK - Published: 2010-11-01 - Publisher: Biota Publishing

GET EBOOK

Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mix
Gutbliss
Language: en
Pages: 306
Authors: Robynne Chutkan M.D.
Categories: Health & Fitness
Type: BOOK - Published: 2014-10-07 - Publisher: Penguin

GET EBOOK

A renowned physician shares her complete 10-day digestive tune-up for women, with important revelations about good gastrointestinal health. Many so-called cures
Eating for IBS
Language: en
Pages: 390
Authors: Heather Van Vorous
Categories: Health & Fitness
Type: BOOK - Published: 2023-05-16 - Publisher: Hachette Go

GET EBOOK

The essential dietary guide and cookbook for people with irritable bowel syndrome and other gastrointestinal disorders--with hundreds of low-fat recipes to ease
Rifaximin, a Poorly Absorbed Antibiotic
Language: en
Pages: 140
Authors: C. Scarpignato
Categories: Medical
Type: BOOK - Published: 2005-01-01 - Publisher: Karger Medical and Scientific Publishers

GET EBOOK

Rifaximin is a semisynthetic rifamycin which is not absorbed from the gastrointestinal tract. It has been available in Europe and other countries for several ye
Irritable Bowel Syndrome and Diverticulosis
Language: en
Pages: 0
Authors: Shirley Trickett
Categories: Health & Fitness
Type: BOOK - Published: 2011-05-01 - Publisher: Conari Press

GET EBOOK

Irritable Bowel Syndrome is an extremely common disorder that is diagnosed in 50% of cases by people who have consulted a gastroenterologist. Symptoms vary from