Innovations for Next-Generation Antibody-Drug Conjugates

Innovations for Next-Generation Antibody-Drug Conjugates
Author :
Publisher : Springer
Total Pages : 358
Release :
ISBN-10 : 9783319781549
ISBN-13 : 3319781545
Rating : 4/5 (545 Downloads)

Book Synopsis Innovations for Next-Generation Antibody-Drug Conjugates by : Marc Damelin

Download or read book Innovations for Next-Generation Antibody-Drug Conjugates written by Marc Damelin and published by Springer. This book was released on 2018-05-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.


Innovations for Next-Generation Antibody-Drug Conjugates Related Books

Innovations for Next-Generation Antibody-Drug Conjugates
Language: en
Pages: 358
Authors: Marc Damelin
Categories: Medical
Type: BOOK - Published: 2018-05-29 - Publisher: Springer

GET EBOOK

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of
Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
Language: en
Pages: 191
Authors: Ulf Grawunder
Categories: Medical
Type: BOOK - Published: 2017-04-07 - Publisher: Springer

GET EBOOK

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the cur
Antibody-Drug Conjugates
Language: en
Pages: 474
Authors: Kenneth J. Olivier, Jr.
Categories: Medical
Type: BOOK - Published: 2016-11-14 - Publisher: John Wiley & Sons

GET EBOOK

Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety a
Cytotoxic Payloads for Antibody–Drug Conjugates
Language: en
Pages: 502
Authors: David E Thurston
Categories: Medical
Type: BOOK - Published: 2019-07-11 - Publisher: Royal Society of Chemistry

GET EBOOK

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and
Antibody-Drug Conjugates
Language: en
Pages: 248
Authors: Jeffrey Wang
Categories: Medical
Type: BOOK - Published: 2015-03-05 - Publisher: Springer

GET EBOOK

This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections includin