Decoding the Antibody Repertoire

Decoding the Antibody Repertoire
Author :
Publisher : Springer
Total Pages : 105
Release :
ISBN-10 : 9783319585185
ISBN-13 : 3319585185
Rating : 4/5 (185 Downloads)

Book Synopsis Decoding the Antibody Repertoire by : Brandon DeKosky

Download or read book Decoding the Antibody Repertoire written by Brandon DeKosky and published by Springer. This book was released on 2017-05-29 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases. Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. The author directly addresses these limitations by designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells. The techniques developed in this work have enabled comprehensive interrogation of human B-cell repertoires and have been applied for rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.


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