Arrest chemokines

Arrest chemokines
Author :
Publisher : Frontiers Media SA
Total Pages : 109
Release :
ISBN-10 : 9782889194308
ISBN-13 : 2889194302
Rating : 4/5 (302 Downloads)

Book Synopsis Arrest chemokines by : Klaus Ley

Download or read book Arrest chemokines written by Klaus Ley and published by Frontiers Media SA. This book was released on 2015-05-20 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration.


Arrest chemokines Related Books

Arrest chemokines
Language: en
Pages: 109
Authors: Klaus Ley
Categories: Chemokines
Type: BOOK - Published: 2015-05-20 - Publisher: Frontiers Media SA

GET EBOOK

Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have bee
Leukocyte Trafficking
Language: en
Pages: 557
Authors: Alf Hamann
Categories: Medical
Type: BOOK - Published: 2006-05-12 - Publisher: John Wiley & Sons

GET EBOOK

Written by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a de
The Chemokine Receptors
Language: en
Pages: 412
Authors: Jeffrey K. Harrison
Categories: Medical
Type: BOOK - Published: 2007-11-17 - Publisher: Springer Science & Business Media

GET EBOOK

This volume, new to The Receptors series, focuses on several areas, including the birth, maturation, and structure of Chemokines; Neutrophil, Dendritic, and Lym
The Mif Handbook
Language: en
Pages: 399
Authors: Richard Bucala
Categories: Medical
Type: BOOK - Published: 2012-05-15 - Publisher: World Scientific

GET EBOOK

The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmu
Regulation of Chemokine Function by Glycosaminoglycan Binding and Oligomerization
Language: en
Pages: 322
Authors: Elaine Ka-Yee Lau
Categories:
Type: BOOK - Published: 2004 - Publisher:

GET EBOOK