Download or read book The Journal of Pharmacology and Experimental Therapeutics, 1917-1918, Vol. 10 (Classic Reprint) written by John J. Abel and published by Forgotten Books. This book was released on 2016-08-09 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excerpt from The Journal of Pharmacology and Experimental Therapeutics, 1917-1918, Vol. 10 It is clear that for this purpose everything depends upon the delicacy of the reactions relied upon for the detection and assay of epinephrin. We made assays with the denervated eye and blood pressure reactions by determining the amounts of adrenalin which must be injected to give approximately the same reaction as the blood released from the cava pocket. When these re actions were found to be absent after the nerve section the amount Oi adrenalin was determined which could just be de tected in this way with certainty. An upper limit was thus fixed to the possible amount Of the residual epinephrin. In using these eye reactions, however, the epinephrin - containing blood is necessarily greatly diluted before it reaches the reacting struc tures. These Observations have accordingly been supplemented by a series of experiments in which the blood was drawn off from the cava pocket and tested directly on rabbit intestine and uterus segments. The normal output of epinephrin, under the experi mental conditions, as assayed by the eye (and blood pressure) reactions in eight cats was found to range from to mgm. Per animal per minute (average, The output per minute per kilo of body weight ranged from to mgm. (average The data Of six of these cats have already been published in the previous paper, on spontaneous liberation of epinephrin.1 The Observations on the remaining two are given in table 1. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.