Download or read book Signaling Mechanisms Regulating the Dual Function Transcription Factor/protein Phosphatase Eyes Absent During Drosophila Eye Development written by Santiago Alejandro Morillo Salazar and published by . This book was released on 2012 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: In addition, I have contributed to a study examining the functions of the Abl kinase in patterning the Drosophila retina. Abl was previously identified as a regulator of Eya during photoreceptor morphogenesis, and here we show that Abl is also required for cell fate maintenance. Loss of Abl results in loss of neuronal markers in photoreceptor cells during late pupal stages and this correlates with upregulation of Notch signaling. Our results reveal developmental plasticity in photoreceptor cells and suggest a novel mechanism for terminal cell fate maintenance.