Download or read book Investigating the Molecular Basis of Protein Aggregation and Alzheimer's Disease with Multi-scale Computer Simulations written by Mary Griffin Krone and published by ProQuest. This book was released on 2007 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of disorders are associated with the deposition of a variety insoluble protein aggregates. A great deal of evidence has led to the hypothesis that there exists a commonality between the aggregation processes of this diverse body of proteins and peptides. Understanding the universally applicable factors which influence the formation and stability of protein aggregates will provide a better understanding of the diseases to which they lead. To this end, we study several intrinsic and environmental factors which influence protein aggregation, including the role of water, the amount of frustration inherent in the individual proteins, confinement, and protein-surface interactions.