Chemical Carcinogenesis

Chemical Carcinogenesis
Author :
Publisher : Springer Science & Business Media
Total Pages : 447
Release :
ISBN-10 : 9781617379956
ISBN-13 : 1617379956
Rating : 4/5 (956 Downloads)

Book Synopsis Chemical Carcinogenesis by : Trevor M. Penning

Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.


Chemical Carcinogenesis Related Books

Chemical Carcinogenesis
Language: en
Pages: 447
Authors: Trevor M. Penning
Categories: Medical
Type: BOOK - Published: 2011-03-03 - Publisher: Springer Science & Business Media

GET EBOOK

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that
Cancer Risk Assessment
Language: en
Pages: 727
Authors: Ching-Hung Hsu
Categories: Science
Type: BOOK - Published: 2010-12-08 - Publisher: John Wiley & Sons

GET EBOOK

With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characteriz
Potential Carcinogenic Hazards from Drugs
Language: en
Pages: 252
Authors: R. Truhaut
Categories: Medical
Type: BOOK - Published: 2012-04-09 - Publisher: Springer

GET EBOOK

Mechanisms of Carcinogenesis
Language: en
Pages: 210
Authors: Elizabeth K. Weisburger
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

GET EBOOK

but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, althou
Carcinogens and Anticarcinogens in the Human Diet
Language: en
Pages: 434
Authors: National Research Council
Categories: Nature
Type: BOOK - Published: 1996-03-12 - Publisher: National Academies Press

GET EBOOK

Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the