Checkpoint Controls and Cancer

Checkpoint Controls and Cancer
Author :
Publisher : Springer Science & Business Media
Total Pages : 328
Release :
ISBN-10 : 9781592597888
ISBN-13 : 1592597882
Rating : 4/5 (882 Downloads)

Book Synopsis Checkpoint Controls and Cancer by : Axel H. Schönthal

Download or read book Checkpoint Controls and Cancer written by Axel H. Schönthal and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal stresses can be generated by the continuous assault of DNA-damaging agents, such as environmental mutagens, ultraviolet (UV) light, ionizing radiation, or the reactive oxygen species that can arise during normal cellular metabolism. In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA repair, or elimination of the cell by cell death (apoptosis) if the damage cannot be repaired. Moreover, internal errors can occur during the highly orchestrated replication of the cellular genome and its distribution into daughter cells. Here, the temporal order of these cell cycle events must be strictly enforced—for example, to ensure that DNA replication is c- plete and occurs only once before cell division, or to monitor mitotic spindle assembly, and to prevent exit from mitosis until chromosome segregation has been completed. Thus, well functioning checkpoint mechanisms are central to the maintenance of genomic integrity and the basic viability of cells and, the- fore, are essential for proper development and survival. The importance of proper functioning of checkpoints becomes plainly obvious under conditions in which this control network malfunctions and fails. Depending on the severity and timing, failure of this machinery can lead to embryonic lethality, genetic diseases, and cancer.


Checkpoint Controls and Cancer Related Books

Checkpoint Controls and Cancer
Language: en
Pages: 358
Authors: Axel H. Schönthal
Categories: Medical
Type: BOOK - Published: 2004-06-24 - Publisher: Humana

GET EBOOK

Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal s
Cell Cycle Checkpoint Control Protocols
Language: en
Pages: 376
Authors: Howard B. Lieberman
Categories: Science
Type: BOOK - Published: 2003-11-14 - Publisher: Humana Press

GET EBOOK

The field of cell cycle regulation is based on the observation that the life cycle of a cell progresses through several distinct phases, G1, M, S, and G2, occur
Checkpoint Controls and Cancer
Language: en
Pages: 328
Authors: Axel H. Schönthal
Categories: Medical
Type: BOOK - Published: 2008-02-05 - Publisher: Springer Science & Business Media

GET EBOOK

Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal s
Regulation of Cancer Immune Checkpoints
Language: en
Pages: 657
Authors:
Categories: Cancer
Type: BOOK - Published: 2020 - Publisher:

GET EBOOK

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely une
Checkpoint Responses in Cancer Therapy
Language: en
Pages: 320
Authors: Wei Dai
Categories: Medical
Type: BOOK - Published: 2008-05-01 - Publisher: Springer Science & Business Media

GET EBOOK

Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes