Download or read book Changes in Endometrial Gene Expression During the Peri-implantation Period in the Rat [microform] written by David Simmons and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2002 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: GRP78, a molecular chaperone residing in the endoplasmic reticulum, was identified by mRNA differential display as having an expression pattern unique to the maximally sensitized endometrium. Specifically, an induction of Grp78 mRNA and protein within the uterine glandular epithelium of the maximally sensitized/receptive endometrium is reported. The hormonal regulation of Grp78 by P4 and E2 appears to be indirect as maximal induction of Grp78 mRNA requires 48 h of progesterone priming followed by exposure to estrogen, the same hormonal requirements for the onset of receptivity/sensitization. (Abstract shortened by UMI.).