Carbonic Anhydrase as Drug Target

Carbonic Anhydrase as Drug Target
Author :
Publisher : Springer
Total Pages : 358
Release :
ISBN-10 : 9783030127800
ISBN-13 : 303012780X
Rating : 4/5 (80X Downloads)

Book Synopsis Carbonic Anhydrase as Drug Target by : Daumantas Matulis

Download or read book Carbonic Anhydrase as Drug Target written by Daumantas Matulis and published by Springer. This book was released on 2019-05-21 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.


Carbonic Anhydrase as Drug Target Related Books

Carbonic Anhydrase as Drug Target
Language: en
Pages: 358
Authors: Daumantas Matulis
Categories: Science
Type: BOOK - Published: 2019-05-21 - Publisher: Springer

GET EBOOK

This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) wit
Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
Language: en
Pages: 429
Authors: Susan C. Frost
Categories: Medical
Type: BOOK - Published: 2013-10-22 - Publisher: Springer Science & Business Media

GET EBOOK

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibit
The Carbonic Anhydrases
Language: en
Pages: 614
Authors: W.R. Chegwidden
Categories: Science
Type: BOOK - Published: 2013-11-11 - Publisher: Birkhäuser

GET EBOOK

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis
The Carbonic Anhydrases
Language: en
Pages: 374
Authors: N.D. Carter
Categories: Science
Type: BOOK - Published: 2013-06-29 - Publisher: Springer Science & Business Media

GET EBOOK

As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted,
Carbonic Anhydrase
Language: en
Pages: 560
Authors: Claudiu T. Supuran
Categories: Medical
Type: BOOK - Published: 2004-05-27 - Publisher: CRC Press

GET EBOOK

Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research.