Autologous and Cancer Stem Cell Gene Therapy

Autologous and Cancer Stem Cell Gene Therapy
Author :
Publisher : World Scientific
Total Pages : 489
Release :
ISBN-10 : 9789812775863
ISBN-13 : 9812775862
Rating : 4/5 (862 Downloads)

Book Synopsis Autologous and Cancer Stem Cell Gene Therapy by : Roger Bertolotti

Download or read book Autologous and Cancer Stem Cell Gene Therapy written by Roger Bertolotti and published by World Scientific. This book was released on 2008 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells provide for life-long cell replacement in tissues and organs, and have inherent homing abilities that are critical in therapeutic applications. Stem cells are also the driving force of cancer where genetic/epigenetic alterations culminate in tumorigenesis either in tissue stem cells or in some of their derivatives. As a rare subset of the tumor, cancer stem cells are the only drive of tumor initiation/propagation. Autologous and cancer stem cells are thus the key targets of 1) long-term and transient-regenerative/epigenetic gene therapy and 2) of recurrence-free anticancer therapy, respectively. While cancer stem cell gene therapy still needs time to accomplish, autologous stem cells have been instrumental in the first unequivocal successes for gene therapy whereby ex vivo retrovirally corrected hematopoietic stem cells have been returned to the patients.This timely book presents 1) the aforementioned stem cell gene therapy achievements that rely on random-integration of therapeutic transgenes into host chromosomes and 2) emerging experimental approaches aimed at eliminating random-integration oncogenic hazards through site-specific integration or gene targeting. Breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders) culminating in an efficiency compatible with clinical trials is one of the highlights of the book. Highlights also include the pioneering transplantation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells able to contribute to all three germ layers. Stem cell gene therapy is thus discussed in terms of 1) magnifying stem cell therapeutic homing through transient regenerative gene therapy and 2) of tackling most pathologies (including mitochondrial DNA diseases and ageing disorders) through stem cell repopulation dynamics into appropriate niches (long-term engraftment) and tissues (cell turn-over). Regarding cancer stem cell gene therapy, focus is on both the increasing number of identified tissue-specific cancer stem cells as the ultimate therapeutic targets and on the development of armed stem cells as tumor-homing vectors for targeted anticancer therapy.


Autologous and Cancer Stem Cell Gene Therapy Related Books

Autologous and Cancer Stem Cell Gene Therapy
Language: en
Pages: 489
Authors: Roger Bertolotti
Categories: Medical
Type: BOOK - Published: 2008 - Publisher: World Scientific

GET EBOOK

Stem cells provide for life-long cell replacement in tissues and organs, and have inherent homing abilities that are critical in therapeutic applications. Stem
Stem Cells and the Future of Regenerative Medicine
Language: en
Pages: 112
Authors: Institute of Medicine
Categories: Science
Type: BOOK - Published: 2002-01-25 - Publisher: National Academies Press

GET EBOOK

Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€
Human Embryonic Stem Cells
Language: en
Pages: 488
Authors: Arlene Chiu
Categories: Science
Type: BOOK - Published: 2003-08 - Publisher: Springer Science & Business Media

GET EBOOK

A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On t
Mesenchymal Stem Cell Therapy
Language: en
Pages: 458
Authors: Lucas G. Chase
Categories: Science
Type: BOOK - Published: 2012-12-12 - Publisher: Springer Science & Business Media

GET EBOOK

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal c
Adipose-Derived Stem Cells
Language: en
Pages: 474
Authors: Jeffrey M. Gimble
Categories: Science
Type: BOOK - Published: 2011-08-24 - Publisher: Humana Press

GET EBOOK

During the past decade, a wide range of scientific disciplines have adopted the use of adipose-derived stem/stromal cells (ASCs) as an important tool for resear