Streptomyces in Nature and Medicine

Streptomyces in Nature and Medicine
Author :
Publisher : Oxford University Press
Total Pages : 261
Release :
ISBN-10 : 9780195150667
ISBN-13 : 019515066X
Rating : 4/5 (66X Downloads)

Book Synopsis Streptomyces in Nature and Medicine by : D. A. Hopwood

Download or read book Streptomyces in Nature and Medicine written by D. A. Hopwood and published by Oxford University Press. This book was released on 2007-02-03 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.


Streptomyces in Nature and Medicine Related Books

Streptomyces in Nature and Medicine
Language: en
Pages: 261
Authors: D. A. Hopwood
Categories: Medical
Type: BOOK - Published: 2007-02-03 - Publisher: Oxford University Press

GET EBOOK

This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as wel
Genetic Manipulation of Streptomyces
Language: en
Pages: 378
Authors: D. A. Hopwood
Categories: Gene expression
Type: BOOK - Published: 1985 - Publisher:

GET EBOOK

The Actinomycetes
Language: en
Pages: 348
Authors: Selman Abraham Waksman
Categories: Actinomycetaceae
Type: BOOK - Published: 1959 - Publisher:

GET EBOOK

Actinobacteria
Language: en
Pages: 401
Authors: Dharumadurai Dhanasekaran
Categories: Science
Type: BOOK - Published: 2016-02-11 - Publisher: BoD – Books on Demand

GET EBOOK

This book presents an introductory overview of Actinobacteria with three main divisions: taxonomic principles, bioprospecting, and agriculture and industrial ut
Actinomycetes
Language: en
Pages: 362
Authors: Evi Stegmann
Categories:
Type: BOOK - Published: 2020-09-04 - Publisher:

GET EBOOK

Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new ant